Andy Card’s resignation comes during calls for a major shake-up of the White House staff.WASHINGTON (CNN) — Amid calls to inject fresh blood into his White House staff, President Bush announced Tuesday that his chief of staff, Andrew Card, has resigned and will be replaced by budget director Josh Bolten.

"Andy Card has served me and our country in historic times," the president said in making his announcement from the White House, with Card and Bolten by his side.

Card served "on a terrible day when America was attacked, during economic recession and recovery, through storms of unprecedented destructive power, in peace and in war," Bush said.

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